Frequency of Frontal Hypometabolism in Autopsy Confirmed AD Subjects 

 
   Lead Investigator:    Norman Foster
   Institution      :    University of Utah, Center for Alzheimer's Care
   E-Mail           :    norman.foster@hsc.utah.edu
   Proposal ID      :    60



   Proposal Description:
   Specific Aims: Identify and calculate the frequency of cerebral metabolic patterns of  hypometabolism that are typically associated with AD and FTD from FDG-PET brain  scans within patients who have autopsy confirmed AD.  Research Question: The classic metabolic abnormality associated with AD seen in  FDG-PET scans is hypometabolism in the temporo-parietal regions. Do autopsy  confirmed AD patients also exhibit metabolic patterns of hypometabolism in their FDGPET  scans that show more frontal hypometabolism in the frontal- temporal cortices than  in the posterior regions of parietal-temporal cortices?  Hypotheses: The FTD-like pattern of cerebral hypometabolism is very uncommon in  patients with autopsy confirmed AD.